Middle East Agricultural Health Study.
نویسندگان
چکیده
Cancer chemotherapy should aim to benefit patients by improving either the duration of survival or the quality of that survival. Patient survival is measured easily, but valid methods for the assessment of physical, social and emotional health have been more difficult to develop. The definition of quality of life (QL) is essentially a philosophical problem and there are no "gold standards" to which QL assessments can be compared. However the development of reliable measures of QL is important since the aim of most trials of chemotherapy is palliation, and the assumption that tumour shrinkage correlates with overall benefit to patients may not always be justified. A number of methods for assessing QL have been reported, including the QL Index (Spitzer et al., 1981): The Sickness Impact Profile (Berger et al., 1981a, b); and linear analogue self-assessment (LASA) (Priestman & Baum, 1976). A QL instrument based upon LASA technique has been developed at this institute and is the subject of a previous report (Selby et al., 1984). This instrument appears to be a valid measure of QL parameters, gives reproducible results and is manageable in the clinical setting. In the present study we have applied the QL instrument to two groups of patients taking part in a randomized trial of the use of either high dose or low dose chemotherapy for metastatic breast cancer. We have used the instrument to address three questions: (i) Does the instrument allow discrimination between two groups of patients with similar disease parameters but whose treatment would be expected to elicit quite different levels of toxicity? (ii) How is patient recall of chemotheray toxicity influenced by the timing of QL assessment in relation to chemotherapy? (iii) What agreement is there between patient and physician assessment of the same aspect of QL?
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 103 شماره
صفحات -
تاریخ انتشار 1995